Cisplatin injection pfizer. 1 months on the etoposide with cisplatin arm (Log rank p=0.

Cisplatin injection pfizer Injection site reactions: Injection site reactions, including erythema, pain at injection site, and vein discoloration, occurred in approximately one third of patients; 5% were severe. 5 × ULN concomitant with alkaline phosphatase >2. paclitaxel injection, USP Indications and Usage INDICATIONS AND USAGE Paclitaxel Injection, USP is indicated as subsequent therapy for the treatment of advanced carcinoma of the ovary. Cisplatin Injection is Dec 3, 2024 · Nephrotoxicity: cisplatin injection can cause severe renal toxicity, including acute renal failure. The aquation of carboplatin, which is thought to produce the active ADVERSE EXPERIENCES IN PATIENTS WITH OVARIAN CANCER SWOG STUDY Carboplatin Arm Percent* Cisplatin Arm Percent* P-Values** Bone Marrow Thrombocytopenia 3<100,000/mm 59 35 <0. Cisplatin is a heavy metal complex containing a central atom of platinum surrounded docetaxel injection, USP 20 mg/ml VIAL Clinical Pharmacology Patient information 12 CLINICAL PHARMACOLOGY 12. Each mL of DBL Cisplatin Injection contains 1 mg cisplatin. An established combination consists of Cisplatin Injection and cyclophosphamide. Each mL of Cisplatin Injection contains: 1 mg cisplatin USP, 9 mg sodium chloride, hydrochloric acid and/or sodium hydroxide to adjust pH, and Water for Injection to a final volume of 50 mL or 100 mL. Bone marrow suppression is the dose-limiting toxicity of carboplatin. OvarianCancer: 1,000 mg/m2 over 30 minutes on Days1 and 8 of each Cisplatin. I. Home Our Products Product Listing DBL™ CARBOPLATIN INJECTION 1. (5. Other ingredients include: • hydrochloric acid • sodium hydroxide • sodium chloride • mannitol • water for injections. Aug 2, 2018 · Pfizer Ltd Ramsgate Road Sandwich, Kent CT13 9NJ United Kingdom +00 44 (0)1304 616161 Revision date: 02-Aug-2018 Emergency telephone number: CHEMTREC (24 hours): 1-800-424-9300 Emergency telephone number: International CHEMTREC (24 hours): +1-703-527-3887 Version: 3. 015, two-sided). Use highly effective antiemetic premedication [see Dosage and Administration (2. For the full list of excipients, see Section 6. pemetrexed disodium (solution) vial (pemetrexed for injection) Indications and Usage 1 INDICATIONS AND USAGE 1. 1 Ovarian Cancer Recommended Dose and Schedule The recommended dosage of gemcitabine is 1,000 mg/m2 intravenously over 30 minutes on Days 1 and 8 of each 21-day cycle in combination with carboplatin AUC 4 administered Specifically, in one report of 2 children receiving concomitant cisplatin with bleomycin, total body clearance of bleomycin decreased from 39 to 18 mL/min/m 2 as the cumulative dose of cisplatin exceeded 300 mg/m 2. 90 Carboplatin and 106 Cisplatin patients did not undergo second look surgery in SWOG study. PHARMACEUTICAL FORM Freeze dried powder for injection 4. It stops cancer cell growth For more information, go to www. When paclitaxel followed by cisplatin was administered to patients with advanced NSCLC in the ECOG study, the incidences of Grade IV neutropenia were 74% (paclitaxel 135 mg/m 2 /24 hours followed by cisplatin) and 65% (paclitaxel 250 mg/m 2 /24 hours followed by cisplatin and G-CSF) compared with 55% in patients who received cisplatin/etoposide. Carboplatin (number of patients) 11% (24/224) 10% (17/171) Cisplatin (number of patients) 15% (33/223) 10% (17/171) 95% C. Medical Information Page - patient information, ways to contact Pfizer Medical & other resources for Healthcare professionals: CARBOPLATIN, Vial U. The recommended dosage of Gemcitabine Injection is 1250 mg/m2 intravenously over 30 minutes on Days 1 and 8 of each 21-day cycle in combination with cisplatin 100 mg/m2 administered intravenously on Day 1 after Gemcitabine Injection administration. 001 DEFINITION. 4)-----DOSAGE AND ADMINISTRATION-----Gemcitabine for injection, USPis for intravenous use only. Know uses, side Cisplatin is also sometimes used to treat head and neck cancer (including cancer of the mouth, lip, cheek, tongue, palate, throat, tonsils, and sinuses), lung cancer, cancer of the cervix and esophagus, brain tumors, malignant pleural mesothlioma (cancer in the lining of the chest or abdomen), and neuroblastoma (a cancer that begins in nerve cells and occurs mainly in children). Diluted Cisplatin Injection BP solution is suitable for intravenous infusion. 3 Non-Small Cell Lung Cancer. WARNING: NEPHROTOXICITY, PERIPHERAL NEUROPATHY, NAUSEA AND VOMITING, and MYELOSUPPRESSION . Your doctor will determine the dose of Carboplatin Injection for you based on your weight, height, and kidney function. Pre-treatment Hydration:Hydration may be achieved by intravenous infusion of 2litres of 5% glucose in ½to ⅓normal saline infused over a 2-4hour period. This effect is apparently cell-cycle nonspecific. NAME OF THE MEDICINE Carboplatin 2. The objective response rate for the gemcitabine with cisplatin arm was 33% compared to 14% on the etoposide with cisplatin arm (Fisher's Exact p=0. Docetaxel Injection in combination with doxorubicin and cyclophosphamide is indicated for the adjuvant treatment of patients with operable node-positive breast cancer. Cisplatin is teratogenic and embryotoxic in mice. ) Inventory - United States TSCA - Sect. CISPLATIN for injection, for intravenous use Initial U. The recommended dose of Pemetrexed for Injection when administered with cisplatin in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m 2 as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle until disease progression or unacceptable toxicity. Cisplatin injection, Hikma, 1 mg/mL, 100 mL vial, 1 count, NDC 00143-9505-01 CARBOPLATIN - U. (b)Preparation of Cisplatin infusion: Cisplatin should be added to 1 liter of sodium chloride IV infusion 0. Please consult a qualified health professional for more detailed information. Avoid use of Docetaxel Injection if bilirubin > ULN, or if AST and/or ALT >1. (1. QUALITATIVE AND QUANTITATIVE COMPOSITION DBL Carboplatin Injection is a sterile solution of carboplatin in Water for Injections and is presented in vials containing 5, 15, or 45 mL of 10 milligrams/mL carboplatin. carboplatin injection Clinical Pharmacology Patient information CLINICAL PHARMACOLOGY Carboplatin, like cisplatin, produces predominantly interstrand DNA cross-links rather than DNA-protein cross-links. 0% of the labeled amount of cisplatin (Cl 2 H 6 N 2 Pt). com Version: 1. 3. com. To procure Cisplatin Injection legally, you can call us at 9643240915 (Mr. The recommended dose of Pemetrexed for Injection, administered as a single agent or with cisplatin, in patients with creatinine clearance of 45 mL/minute or greater is 500 mg/m 2 as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle. pfizer. El uso de cisplatin tal vez aumente su riesgo de desarrollar leucemia. Given the possibility of extravasation, it is recommended to closely monitor the infusion site for possible infiltration during drug administration. 7. 1 Therapeutic Indications DBLGemcitabine Injection is Hydrochloride for Injection [see Use in Specific Populations (8. Pfizer Ltd Ramsgate Road Sandwich, Kent CT13 9NJ United Kingdom +00 44 (0)1304 616161 Emergency telephone number: CHEMTREC (24 hours): 1-800-424-9300 Revision date: 30-Mar-2011 Emergency telephone number: ChemSafe (24 hours): +44 (0)208 762 8322 Contact E-Mail: pfizer-MSDS@pfizer. A total of 452 patients were randomized (1:1:1:1) to receive paclitaxel and cisplatin with or without bevacizumab, or paclitaxel and topotecan with or without bevacizumab. x Myelosuppression: cisplatin for injection can cause severe myelosuppression with fatalities due to infections. Monitor renal function. For gastric adenocarcinoma, the recommended dose of Docetaxel Injection is 75 mg/m 2 as a 1 hour intravenous infusion, followed by cisplatin 75 mg/m 2, as a 1 to 3 hour intravenous infusion (both on day 1 only), followed by fluorouracil 750 mg/m 2 per day given as a 24-hour continuous intravenous infusion for 5 days, starting at the end of the Tables 11 and 12 present the incidence of selected adverse reactions and laboratory abnormalities, occurring in ≥10% of gemcitabine-treated patients and at a higher incidence in the gemcitabine with cisplatin arm, reported in a randomized trial (Study 3) of gemcitabine with cisplatin (n=260) administered in 28-day cycles as compared to Dec 18, 2018 · Implications for Patient Care. LFT elevations increase risk of severe or life-threatening complications. PHARMACEUTICAL FORM DBLGemcitabine Injection is a clear, colourless to light straw-coloured solution for intravenous use. Docetaxel binds to free tubulin and Tables 13 and 14 present the incidence of selected adverse reactions and laboratory abnormalities occurring in ≥10% of gemcitabine-treated patients and at a higher incidence in the gemcitabine with cisplatin arm, reported in a randomized trial (Study 4) of gemcitabine with cisplatin (n=69) administered in 21-day cycles as compared to For gastric adenocarcinoma, the recommended dose of Docetaxel Injection is 75 mg/m 2 as a 1 hour intravenous infusion, followed by cisplatin 75 mg/m 2, as a 1 to 3 hour intravenous infusion (both on day 1 only), followed by fluorouracil 750 mg/m 2 per day given as a 24-hour continuous intravenous infusion for 5 days, starting at the end of the For patients who are dosed initially at Docetaxel Injection 75 mg/m 2 in combination with cisplatin, and whose nadir of platelet count during the previous course of therapy is <25,000 cells/mm 3, in patients who experience febrile neutropenia, and in patients with serious non-hematologic toxicities, the Docetaxel Injection dosage in subsequent minutes of the pretreatment hydration or after the hydration, 375 mL of 10% mannitol injection may be administered via a side-arm drip. carboplatin injection Description Patient information DESCRIPTION Carboplatin Injection is supplied as a sterile, pyrogen-free, aqueous solution available in 50 mg/5 mL, 150 mg/15 mL, 450 mg/45 mL or 600 mg/60 mL multiple-dose vials containing 10 mg/mL of carboplatin for administration by intravenous infusion. 8(b) Present Australia (AICS): Present Hematologic Toxicity. received either paclitaxel 135 mg/m2 infused over 24 hours followed by cisplatin 75 mg/m2 or cyclophosphamide 750 mg/m 2 followed by cisplatin 75 mg/m for 6 courses. Aluminium containing equipment should not be used for administration of cisplatin (see Aug 7, 2023 · Cisplatin is a platinum-based chemotherapy agent, prescribed for ovarian cancer, bladder cancer and metastatic testicular tumors either alone or with other medications. ToposarTM 817 607 000 etoposide injection, USP WARNINGS TOPOSAR (etoposide injection, USP) should be administered under the supervision of a qualified physician experienced in the use of cancer pemetrexed disodium (solution) vial (pemetrexed for injection) What is Pemetrexed Injection? Patient information What is Pemetrexed Injection? Pemetrexed Injection is a prescription medicine used to treat: a kind of lung cancer called non-squamous non-small cell lung cancer (NSCLC). Physician Prescribing Information Pfizer Inc Pfizer Pharmaceuticals Group 235 East 42nd Street New York, New York 10017 1-212-573-2222 Pfizer Ltd Ramsgate Road Sandwich, Kent CT13 9NJ United Kingdom +00 44 (0)1304 616161 Emergency telephone number: CHEMTREC (24 hours): 1-800-424-9300 Revision date: 20-Jun-2011 Emergency telephone number: ChemSafe (24 hours): +44 (0)208 762 8322 When paclitaxel followed by cisplatin was administered to patients with advanced NSCLC in the ECOG study, the incidences of Grade IV neutropenia were 74% (paclitaxel 135 mg/m 2 /24 hours followed by cisplatin) and 65% (paclitaxel 250 mg/m 2 /24 hours followed by cisplatin and G-CSF) compared with 55% in patients who received cisplatin/etoposide. Taj Pharmaceuticals Corporation Information Table 171. Close monitoring of kidney function and blood cell count are necessary while receiving this medication. The recommended dose of Pemetrexed Injection, administered as a single agent or with cisplatin, in patients with creatinine clearance of 45 mL/minute or greater is 500 mg/m 2 as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle. The recommended dose of Pemetrexed Injection when administered with cisplatin for initial treatment of locally advanced or metastatic non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m 2 as an intravenous infusion over 10 minutes administered prior to cisplatin on What is the price of Cisplatin Injection in India? Cisplatin Injection price in India is reasonable and can vary. Cisplatin Injection is a sterile solution of Cisplatin in Water for Injection. See full prescribing information for complete boxed warning. Each 50 mL or 100 mL amber vial of Cisplatin Injection contains: 1 mg/mL cisplatin, 9 mg/mL sodium chloride, hydrochloric acid and/or sodium hydroxide to adjust pH, and water for injection to a final volume of 50 mL or 100 mL, respectively. Carboplatin Injection is given by dripping the medicine slowly and directly into a vein (intravenous infusion) for 15 minutes or longer. x Nausea and Vomiting: cisplatin for injection can cause severe nausea and vomiting. Pemetrexed for Injection is a folate analog metabolic inhibitor indicated: • In combination with cisplatin for the initial treatment of patients with locally advanced or metastatic, non-squamous, non-small cell lung cancer (NSCLC). Pregúntele a su médico sobre su riesgo personal. Cisplatin for Injection, USP Safety Data Sheet (SDS) Version: 1. Injection site reactions . 1, 5. Dosage Modifications Recommended dosage modifications for gemcitabine myelosuppression are described in Table 4 [see Warnings and Precautions (5. carboplatin injection Clinical Pharmacology CLINICAL PHARMACOLOGY Carboplatin, like cisplatin, produces predominantly interstrand DNA cross-links rather than DNA-protein cross-links. 3)]. 0 mg / mL (10 mg / 10 mL, 50 mg / 50 mL,) THERAPEUTIC CLASSIFICATION Antineoplastic Agent CAUTION CISPLATIN INJECTION BP IS A POTENT DRUG AND SHOULD BE USED ONLY BY Median time to disease progression for the gemcitabine with cisplatin arm was 5 months compared to 4. For the full list of excipients, see section 6. PrCisplatin Injection BP – Product Monograph Page 6 of 31 Dilute the prepared Cisplatin Injection BP in 2 liters of 5% dextrose in one half or one third normal saline, containing 37. Phlebitis (chemical phlebitis) along the vein proximal to the site of injection was reported in 10% of patients. Jul 18, 2024 · When paclitaxel followed by cisplatin was administered to patients with advanced NSCLC in the ECOG study, the incidences of Grade IV neutropenia were 74% (paclitaxel 135 mg/m 2 /24 hours followed by cisplatin) and 65% (paclitaxel 250 mg/m 2 /24 hours followed by cisplatin and G-CSF) compared with 55% in patients who received cisplatin/etoposide. Pre-existing cisplatin-induced neurotoxicity does not worsen in about 70% of the patients receiving carboplatin as secondary treatment. Topotecan Hydrochloride for Injection in combination with cisplatin for the treatment of cervical cancer should only be initiated in patients with serum creatinine ≤1. Injection site reactions. Median time to disease progression for the gemcitabine with cisplatin arm was 5 months compared to 4. 9%. 1 months on the etoposide with cisplatin arm (Log rank p=0. Carboplatin Injection may be given alone or with other drugs. 5 × ULN. 1) and Warnings and Precautions (5. Cisplatin, the active ingredient in Cisplatin for injection, USP, is a yellow to orange crystalline powder with the molecular formula Cl 2 H 6 N 2 Pt and a molecular weight of 300. com pemetrexed disodium (solution) vial (pemetrexed for injection) Indications and Usage Patient information 1 INDICATIONS AND USAGE 1. The See full list on cdn. reduced drug total body clearance. Consider dose reductions or alternative treatments in patients with renal impairment. exports@gmail. Gemcitabine Injection in combination with cisplatin is indicated for the first-line treatment of patients with inoperable, locally advanced (Stage IIIA or IIIB) or metastatic (Stage IV) non-small cell lung cancer (NSCLC). Also find the prescribing information, announcements, resources, and channels to connect with Pfizer Medical Information The recommended dose of Pemetrexed for Injection when administered with cisplatin for initial treatment of locally advanced or metastatic non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m 2 as an intravenous infusion over 10 minutes administered prior to Median time to disease progression for the gemcitabine with cisplatin arm was 5 months compared to 4. children receiving concomitant cisplatin with bleomycin, total body clearance of bleomycin decreased from 39 to 18 mL/min/m2 as the cumulative dose of cisplatin exceeded 300 mg/m2. Hospira(Pfizer) Cisplatin Injection Sales (K Units), Revenue (Million USD), Price (US$/Unit) and Gross Margin (2016-2021) Table 168. 1 Issue Date: June 13, 2019 Page 1 of 12 1. NAME OF THE MEDICINAL PRODUCT CISPLASOL 2. Dosage Modifications 114 Carboplatin and 109 Cisplatin patients did not undergo second look surgery in NCIC study. Nov 16, 2017 · Cisplatin (Pfizer) 50 mg Infusion is an anticancer agent which is used in the treatment of various cancers of the bladder, male and female reproductive system. 2) • Nausea and Vomiting: cisplatin for injection can cause severe nausea and vomiting. 0% and NMT 110. com or call 1-800-438-1985. Page 2 of 21 PRODUCT MONOGRAPH Pr CISPLATIN INJECTION BP Sterile solution 1. Refer to cisplatin prescribing information for additional information. Control antes, durante y después de: función renal, hepática, hematopoyética (nº de eritrocitos, leucocitos y plaquetas), electrolitos séricos (Ca, sodio, K y magnesio) y audiogramas. Thrombocytopenia with platelet counts below 50,000/mm 3 occurs in 25% of the patients (35% of pretreated ovarian cancer patients); neutropenia with granulocyte counts below 1,000/mm 3 occurs in 16% of the patients (21% of pretreated ovarian cancer patients); leukopenia with WBC counts below 2,000/mm 3 in combination with cisplatin,for the treatment of non-small cell lung cancer. Cisplatin, USP is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms and two ammonia molecules in the cis position. (1. Administer furosemide at lower doses and with positive fluid balance when used to achieve forced diuresis during cisplatin treatment. com CISPLATIN INJECTION BP Product Information. It should be used under the supervision of a qualified physician. Fatal bleomycin pulmonary When paclitaxel followed by cisplatin was administered to patients with advanced NSCLC in the ECOG study, the incidences of Grade IV neutropenia were 74% (paclitaxel 135 mg/m 2 /24 hours followed by cisplatin) and 65% (paclitaxel 250 mg/m 2 /24 hours followed by cisplatin and G-CSF) compared with 55% in patients who received cisplatin/etoposide. See full prescribing information for CISPLATIN INJECTION. Cisplatin USP, the active ingredient in Cisplatin Injection, is an orange-yellow crystalline powder with the molecular formula Cl 2 H 6 N 2 Pt and a molecular weight of 300. CLINICAL PARTICULARS 4. of difference (Carboplatin Pfizer Inc Pfizer Pharmaceuticals Group 235 East 42nd Street New York, New York 10017 1-212-573-2222 Pfizer Ltd Ramsgate Road Sandwich, Kent CT13 9NJ United Kingdom +00 44 (0)1304 616161 Emergency telephone number: CHEMTREC (24 hours): 1-800-424-9300 Revision date: 13-Sep-2012 Emergency telephone number: International CHEMTREC (24 hours): +1 Cisplatin Injection is a clear, colorless to pale yellow, sterile aqueous solution. Also find the prescribing information, announcements, resources, and channels to connect with Pfizer Medical Information Carboplatin Injection is contraindicated in patients with a history of severe allergic reactions to cisplatin or other platinum-containing compounds. Cisplatin puede causar daño al bebé nonato si la madre o el padre está usando esta medicina. Product Monograph (download PDF, 230KB) Patient Information (download PDF, 121KB) Canadian regulations limit the scope of information we are permitted to give on prescription drugs via the Internet or other means. 1) • As a single agent for the maintenance treatment of patients with locally Median time to disease progression for the gemcitabine with cisplatin arm was 5 months compared to 4. During combination therapy with cisplatin, serum creatinine, serum potassium, serum calcium, and serum magnesium should be carefully 0monitored (Grade 3/4 serum creatinine toxicity for Gemcitabine for Injection plus cisplatin was 5% Neuropatía periférica no inducida por cisplatino, infecciones agudas bacteriana o víricas, hiperuricemia. (2. Cisplatin Injection, a platinum-based drug for intravenous use, is a clear, light yellow sterile aqueous solution. 4 to 6. Pemetrexed Injection is used: as the first treatment in combination with cisplatin Median time to disease progression for the gemcitabine with cisplatin arm was 5 months compared to 4. In both studies, patients treated with paclitaxel in combination with cisplatin had significantly higher response rate, longer time to progression, and longer survival Injection plus cisplatin should be held or decreased by 50% depending on the judgment of the treating physician. Cisplatin is a platinum-based alkylating agent. For gastric adenocarcinoma, the recommended dose of Docetaxel Injection is 75 mg/m 2 as a 1 hour intravenous infusion, followed by cisplatin 75 mg/m 2, as a 1 to 3 hour intravenous infusion (both on day 1 only), followed by fluorouracil 750 mg/m 2 per day given as a 24-hour continuous intravenous infusion for 5 days, starting at the end of the Although peripheral neurotoxicity is infrequent, its incidence is increased in patients older than 65 years and in patients previously treated with cisplatin. Cisplatin has been shown to be teratogenic, embryotoxic and carcinogenic in mice and rats. 4. 0 MATERIAL SAFETY DATA SHEET Page 1 of 9 Pfizer Inc Product Monograph: PrCisplatin Injection BP Page 2 of 26 PRODUCT MONOGRAPH PrCisplatin Injection BP Sterile solution 1 mg / mL THERAPEUTIC CLASSIFICATION Antineoplastic Agent CAUTION CISPLATIN INJECTION BP IS A POTENT DRUG AND SHOULD BE USED ONLY BY PHYSICIANS EXPERIENCED WITH CANCER CHEMOTHERAPEUTIC DRUGS (SEE WARNINGS AND PRECAUTIONS). Hospira(Pfizer) Recent Development Table 170. 1 Ovarian Cancer Recommended Dose and Schedule The recommended dosage of gemcitabine is 1,000 mg/m2 intravenously over 30 minutes on Days 1 and 8 of each 21-day cycle in combination with carboplatin AUC 4 administered Το cisplatin είναι ένα κυτταροστατικό φάρμακο, που σύμφωνα με μελέτες που πραγματοποιήθηκαν Cisplatin Injection is a clear, pale yellow solution in a plastic vial. Premedicate with antiemetics . . Supplier Pfizer Australia Pty Docetaxel Injection is indicated for the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy. Sana Sadyar), Or Write us at alleviare. cisplatin to ensure good urinary output and minimise nephrotoxicity. Hospira(Pfizer) Cisplatin Injection Product Table 169. Cisplatin and nephrotoxic drugs. com SAFETY DATA SHEET Page 1 of 7 Sep 27, 2021 · Cisplatin for Injection, USP may contain hydrochloric acid for pH adjustment. Carcinogenicity is possible but has not been demonstrated. Nephrotoxicity. Buy Cisplatin (Pfizer) 50 mg Infusion Online. 1 Mechanism of Action Docetaxel is an antineoplastic agent that acts by disrupting the microtubular network in cells that is essential for mitotic and interphase cellular functions. carboplatin injection medication page for healthcare professionals to search for scientific information on Pfizer medications. DBL Cisplatin Injection is a clear, colourless to pale yellow sterile solution of cisplatin 1 mg/mL, mannitol 1 mg/mL and sodium chloride 9 mg/mL in water for injections. 001 • Peripheral Neuropathy: cisplatin for injection can cause dose - related peripheral neuropathy. Do Alleviare Export Cisplatin Cisplatin. Patients on the Docetaxel Injection arm received Docetaxel Injection (T) 75 mg/m 2 by intravenous infusion on day 1 followed by cisplatin (P) 100 mg/m 2 administered as a 30-minute to three-hour intravenous infusion, followed by the continuous intravenous infusion of fluorouracil (F) 1000 mg/m 2 /day from day 1 to day 4. S. 0 hours. 1 List of excipients. Aug 14, 2023 · Un niño tratado con cisplatin puede necesitar una prueba de audición antes de recibir la primera dosis. 3) • Myelosuppression: cisplatin for injection can cause severe myelosuppression with fatalities due to infections. 1. Vinorelbine Injection USP plus Cisplatin versus Vindesine plus Cisplatin versus Single-Agent Vinorelbine Injection USP: In a large European clinical trial, 612 patients with Stage III or IV NSCLC, no prior chemotherapy, and WHO Performance Status of 0, 1, Products Affected - Description. Taj Pharmaceuticals Description and Business 1. com or sana. Also, find the prescribing information, announcements, resources, and channels to connect with Pfizer Medical Information. In the clinical trial, cisplatin was discontinued The recommended dose of Pemetrexed for Injection when administered with cisplatin for initial treatment of locally advanced or metastatic non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m 2 as an intravenous infusion over 10 minutes administered prior to The recommended dosage of Gemcitabine Injection is 1000 mg/m 2 intravenously over 30 minutes on Days 1, 8, and 15 of each 28-day cycle in combination with cisplatin 100 mg/m 2 administered intravenously on Day 1 after Gemcitabine Injection administration. 2 Recommended Dosage for Mesothelioma. Terminal half-life of bleomycin also increased from 4. Cisplatin Injection, as a single agent, is indicated as secondary therapy in patients with metastatic ovarian tumors refractory to standard chemotherapy who have not previously received Cisplatin Injection therapy. sadyar@alleviareindia. As first-line therapy, paclitaxel is indicated in combination with cisplatin. 4 Contact E-Mail: pfizer-MSDS@pfizer. There is a risk of ototoxic effects if cisplatin and furosemide are given concomitantly [see Warnings and Precautions (5. Ensure adequate hydration. The dosing regimens for bevacizumab, paclitaxel, cisplatin and topotecan were as follows: • Day 1: Paclitaxel 135 mg/m 2 over 24 hours, Day 2: cisplatin 50 mg/m 2 with 2. 2)]. QUALITATIVE AND QUANTITATIVE COMPOSITION 10 or 50 mL vials containing 10 or 50 mg cisplatin freeze dried powder for injection. Each mL of DBL Carboplatin Injection contains carboplatin 10mg. 05. Carboplatin Injection should not be employed in patients with severe bone marrow depression or significant bleeding. 3) as a singleagent for the treatment of pancreatic cancer. (Cisplatin) 1. This solution is not preserved and it should be used within 24 hours. 1 Recommended Dosage for Non-Squamous NSCLC. Paclitaxel is indicated for the adjuvant gemcitabine injection powder 2GM Dosage and Administration Patient information 2 DOSAGE AND ADMINISTRATION 2. The recommended dose of Pemetrexed Injection when administered with cisplatin in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m 2 as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle until disease progression or unacceptable toxicity. Specifically, in one report of 2 children receiving concomitant cisplatin with bleomycin, total body clearance of bleomycin decreased from 39 to 18 mL/min/m 2 as the cumulative dose of cisplatin exceeded 300 mg/m 2. The most common side effects of Pemetrexed for Injection when given with cisplatin are: Median time to disease progression for the gemcitabine with cisplatin arm was 5 months compared to 4. The cycles were PRODUCT MONOGRAPH; Cisplatin Injection BP - Accord Healthcare Inc. of each 21-day cycle in combination with cisplatin 100 mg/m2 administered intravenously on Day 1 after gemcitabineadministration. DBLGemcitabine Injection contains no microbial agent or preservatives. 1) Peripheral Neuropathy: cisplatin injection can cause dose-related peripheral neuropathy. Yashpal Singh) 9289711087 (Ms. Nov 2, 2018 · Cisplatin Injection infusion concentrate is a clear, colorless, sterile aqueous solution. Ingredients Cisplatin Injection contains cisplatin as the active ingredient. Administer furosemide at lower doses and with postitive fluid balance when used to achieve forced diuresis during cisplatin treatment. 1 Non-Squamous Non-Small Cell Lung Cancer (NSCLC) Pemetrexed Injection is indicated: In combination with cisplatin for the initial treatment of patients with locally advanced or metastatic, non-squamous, non-small cell The recommended dose of Pemetrexed Injection when administered with cisplatin for initial treatment of locally advanced or metastatic non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m 2 as an intravenous infusion over 10 minutes administered prior to cisplatin carboplatin injection medication page for patients to search for scientific information on Pfizer medications. 2. Connect with Us Investors Careers Media Science Contact Us. 5 g of mannitol. Pfizer Ltd Ramsgate Road Sandwich, Kent CT13 9NJ Reino Unido +00 44 (0)1304 616161 Fecha de revisión: 09-Ago-2016 Teléfono de emergencia: CHEMTREC (las 24 horas): 1-800-424-9300 Teléfono de emergencia: CHEMTREC internacional (las 24 horas): +1-703-527-3887 Versión: 2. 1 Non-Squamous Non-Small Cell Lung Cancer (NSCLC) Pemetrexed Injection is indicated: In combination with cisplatin for the initial treatment of patients with locally advanced or metastatic, non-squamous, non-small cell Table 167. Advanced Bladder Cancer . [8,9,10] Median time to disease progression for the gemcitabine with cisplatin arm was 5 months compared to 4. 3 Correo electrónico de contacto: pfizer-MSDS@pfizer. It contains NLT 90. CISPLATIN INJECTION safely and effectively. It does not contain a preservative. 5 mg/dL. PRODUCT AND COMPANY INFORMATION Distributed By: WG Critical Care, LLC. Prior to use of cisplatin may also result in a decrease of etoposide total body clearance in children. Administration:Cisplatin Injection may be added to 1litre of normal saline and infused over the desired time period. It is labeled for use as a single agent for the treatment of advanced transitional cell bladder cancer, and in combination with other antineoplastic agents for the treatment of metastatic testicular cancer and metastatic ovarian cancer. 120 Route 17 North Suite 115 Paramus, NJ 07652 USA Product Name: Cisplatin for Injection, USP Active Ingredient Primary Component: Cisplatin Structure: 2. Cisplatin is a bacterial mutagen and causes chromosome aberrations in cultures on animal cells. PHARMACEUTICAL FORM Solution for injection. 01, two-sided). gemcitabine injection powder 2GM Dosage and Administration Patient information 2 DOSAGE AND ADMINISTRATION 2. Obtain LFTs before each treatment cycle • Do not administer Docetaxel Injection to patients with neutrophil counts <1500 cells/mm 3. Injection site reactions may occur during the administration of cisplatin. 1. ( 2. Approval: 1978 . THERAPEUTIC INDICATIONS carboplatin injection Clinical Pharmacology CLINICAL PHARMACOLOGY Carboplatin, like cisplatin, produces predominantly interstrand DNA cross-links rather than DNA-protein cross-links. Nov 7, 2018 · Water for Injection Revision date: 07-Nov-2018 CERCLA/SARA 313 Emission reporting Not Listed CERCLA/SARA 313 Emission reporting California Proposition 65 Not Listed Not Listed Material Name: Carboplatin Injection (Hospira, Inc. Vinorelbine Injection USP plus Cisplatin versus Vindesine plus Cisplatin versus Single-Agent Vinorelbine Injection USP: In a large European clinical trial, 612 patients with Stage III or IV NSCLC, no prior chemotherapy, and WHO Performance Status of 0, 1, PrCisplatin Injection BP Product Monograph Page 2 of 20 PRODUCT MONOGRAPH PrCisplatin Injection BP Sterile solution 1 mg / mL THERAPEUTIC CLASSIFICATION Antineoplastic Agent CAUTION CISPLATIN INJECTION BP IS A POTENT DRUG AND SHOULD BE USED ONLY BY PHYSICIANS EXPERIENCED WITH CANCER CHEMOTHERAPEUTIC DRUGS (SEE WARNINGS AND PRECAUTIONS). 0hours. May 14, 2019 · Cisplatin injection may be used singularly or in combination with other chemotherapeutic agents in the treatment of: - metastatic nonseminomatous germ cell carcinoma; advanced stage, refractory ovarian carcinoma; advanced stage, refractory bladder carcinoma; refractory squamous cell carcinoma of the head and neck Median time to disease progression for the gemcitabine with cisplatin arm was 5 months compared to 4. 6) and Clinical Pharmacology (12. The aquation of carboplatin, which is thought to produce the active The recommended dose of Pemetrexed for Injection when administered with cisplatin for initial treatment of locally advanced or metastatic non-squamous NSCLC in patients with a creatinine clearance (calculated by Cockcroft-Gault equation) of 45 mL/min or greater is 500 mg/m 2 as an intravenous infusion over 10 minutes administered prior to Carboplatin Injection is given by dripping the medicine slowly and directly into a vein (intravenous infusion) for 15 minutes or longer. dacl ludba jgvb xprl upsutnal hgdvg fsjd nsvy xbkb semo hjxu ejqpj kzhxlmyj hqib gnodjy