History of drugs ppt History of gmp • Download as PPTX, PDF • 1 like • 1,466 views. e. • The patient was a 15-year-old black male, named Robert R. It then discusses early milestones in drug development in the 19th century with the The document discusses the history and classification of controlled substances in the United States. C. This was also the time when plagues scourged many parts of Europe. the development of antibiotics and drug regimens in the 1940s-1950s, and the World Health Organization's Directly Observed Treatment, Short History of Pharmacy - Download as a PDF or view online for free. Several categories of drugs are The History of Drugs. P- 515721 4 MONOGRAPHS • Pharmacovigilance for ASU Drugs - Download as a PDF or view online for free (PV), defined as the science of detecting, assessing, understanding, and preventing adverse effects of drugs. Do not use drugs prescribed for someone else, and do not share yours. As a proportion of drug abusers, heroin users have 15. 2. He classified medicinal plants on the basis of medicinal characteristics. Four decades ago the Government of Pharmacology is the science of drugs, covering all aspects of drug knowledge. Hospital’s or institution’s role: Provide education on potential LASA medicines. 7. Significant early Greek figures included Dioscorides who wrote an influential 5-volume herbal, and 6. Delve into key milestones, regulatory changes, and the impact of To better understand the tradition each man was continuing and their impacts on future progress, the brief history of pharmacology will be examined in ancient Mesopotamia, ancient Egypt, Classical Greece, Empirical Rome, The Golden 8. Thus, religious persons (priests or shamans) or A pure alkaloid was isolated by Jobst and Hesse in 1864 and named physostigmine. Submit Search. If a drug produces coldness in Drugs are obtained from six major sources: plant sources, animal sources, mineral/earth sources, microbiological sources, semi-synthetic sources, and recombinant DNA technology. History of CT before yr 1750 • Persian physician and philosopher, Avicenna • In The Canon of Medicine, he laid down rules for the experimental use and testing of drugs and wrote a precise guide for practical HISTORY The field of antiviral drugs grew rapidly in the herpes area with the development of acyclovir (Schaffer et al. Consequently, the Federal Food, Drug and Cosmetic Act was established in 1938; its aim was to renovate the public health system. New classifications of drugs are developed 2. Browse predesigned collection of Drug Discovery And Development Process PowerPoint templates, presentation slides graphic designs, PPT slides and infographic. 4. Development of drugs against hepatitis B virus (HBV) has been successful History of Health Care/Medicine. 1 and of salicylic acid 1. from St. HISTORY Penicillin, the world's first antibiotic, was discovered by British scientist Alexander Fleming in 9. This presentation discusses the history and effects of drug use and addiction. K. It then explains why drug addiction is an important global health issue, listing various negative health outcomes associated with drug In their structure, beta-lactam ring is located due to this reason these drugs are also called as beta-lactam antibiotics. It defines pharmacopoeias as official books set by government authorities that establish quality standards for drugs, ingredients, and 9. A Brief History of Drugs and Drug Laws. It may distrupt the body's homeostasis. It is the name given to drug in accordance with rules of chemical nomenclature established by International Union of Pure 7. 000. Historical developments in pharmacology: Theophrastus (380-287 BC): A great philosopher called father of botany. Manjunath Patil Follow. Palli Cross, Chiyyedu, Anantapuramu, A. • In • Download as PPT, PDF • 112 likes • 103,571 views. Drug 1. As the 1980s began, people started seeking treatment to help them stop using stimulants. History of Chemotherapy 1990s 1. A single word of appreciation from you will encourage me to make more of such videos. Find out how the drug may interact with alcohol and with other medications—prescribed or over the counter. • Indian Pharmacopoeial List History and the Present of Prodrug Design 1899 Methenamine First intentional Prodrug 1935 Protonsil Antibiotic 1958 Adrien Albert First introduced the term “pro-drug” 1960 An explosive increase in the use of 4. HISTORY OF DRUG DISCOVERY Drug discovery and development has a long history and dates back to the early days of human civilization. If you like it, please do let me know in the comments section. It outlines the history Ppt history of pharmacy - Download as a PDF or view online for free Early Indian medicine relied on plant, animal, and mineral drugs without standardization, often kept secret in families. Report on GMP manufacturing units and institutes – Dr D S Bhar History of High Potency Machines in 19th Century Drugs made from medicinal plants, herbs, minerals, metallic and animal origin are used for the treatment of diseases. The document then discusses the history of herbal medicine, how herbs work in 3. 000 $. It describes several committees that were formed to address issues with drug quality, regulation of the pharmaceutical industry and pharmacy Drug - Download as a PDF or view online for free. Kausar, Shamaila, Fahad Said Khan, Muhammad Ishaq Mujeeb Ur Rehman, Muhammad Akram 3. 1 week before the admission, the patient fell while gardening and cut his foot with a stone. By Dr. It then covers drug addiction in more detail, explaining causes and effects on the brain. What is a Drug?. " While used medically to treat pain, coughs, 6. ¶ INTRODUCTION:- A medication history is a detailed, accurate and complete account of all prescribed and non-prescribed medications that a patient had taken or is currently taking prior to a newly initiated Continued use of drugs can lead to drug dependence, a state of physical & mental dependence. Discuss the evolution and significant events in the history of medicine. Louis, 5. It begins with a brief history of increasing drug regulation since the early 1900s, culminating in the 1970 Controlled History of gmp - Download as a PDF or view online for free. Prior to WWII, drugs remained for people on the “fringe” of society Prohibition/ Gangster/Mob violence. R. It notes that in 1972, there were only 20,000 drug users in the country and marijuana was the most commonly used drug. Origin In 1811 first chemist shop opened by Mr. • The roots of the ancient Siddha System are intertwined with the mythology and culture of the ancient Tamil 2. 2 were developed in the 1860s and 1870s. INTRODUCTION • Medication history is a part of pharmaceutical consultation that identifies and document allergies or other serious adverse medication events as well as information about how History of Medicinal Chemistry - Download as a PDF or view online for free The development of effective drugs for the treatment of Tuberculosis, Typhoid, Malaria, Infective hepatitis, Tetanus, Cholera etc. Exploration in the This document provides an overview of drugs, including their classification, sources, and history. Antiretroviral drugs (NRTIs) - Zidovudine • Adverse effects: – Toxicity is mainly due to partial inhibition of cellular mitochondrial DNA polymerase γ which has higher affinity for zidovudine triphosphate than The history of preparation and use of medicines dates back to ancient times. 1. A cocaine epidemic started in the 1970s and Anti inflammatory drugs - Download as a PDF or view online for free In patients at high risk for ulcers (that is, history of peptic ulcer disease), use of PPIs with celecoxib and aspirin may be necessary to avoid gastric “Antiviral Drugs–a Short History of Their Discovery and Development. Punjab University Lahore Follow. 47. The genetic basis of cancers become an important factor in cancer risk research 2000s 1. Functional drugs are classified that modulate physiological functions like analgesics, antipyretics, • It is the foremost of all other medical systems in the world. It Antibiotic History - Download as a PDF or view online for free • Download as PPT, PDF • • 1943- Drug companies begin mass production of penicillin • 1948- Cephalosporins precursor sent to Oxford for synthesis • 1952 Objectives for the Lecture At the end of this lecture, the physician should be able to do the following: 1. Classification of crude drugs • Crude drug i. 1 Drug is any substance is intended is used as orally applied a topically for the purpose of used of mitigation, treatment, prevention, cure and Diagnosis of disease and Drugs are then classified in two main ways: by their chemical structure and by their therapeutic action or medicinal use. The Drugs Act has been modified from time to time and at present the provisions of the Act cover Cosmetics and Ayurvedic, Unani and Herbal drugs contain phytochemicals that can have effects on the body and are commonly used as dietary supplements to improve health. Substance that, when ingested, is capable of producing a physiological History of Drugs & Drug Use Background Statistics • Drugs and drug use in the U. 3. Examples of early drug discoveries are- 1. Its origin goes back to B. In the written record, the study of herbs dates back over 5,000 years to the Sumerians, who created clay tablets with lists of hundreds of medicinal plants (such as myrrh and opium)In 1500 B. S. INTRODUCTION Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery. Galen (130 41. Opium and Cannabis were used medicinally - opium in the 14th century by Spanish warriors and introduction to drug discovery,history of drug development , drug development pathways, steps in drug discovery. of blood dyscrasias • During first trimester of It begins by providing a brief history of drug use dating back to ancient civilizations. Since the 19th century when Americans first discovered new wonder drugs like morphine, heroin, and cocaine, our society has confronted the problem of drug abuse and addiction. Unregulated Drug Use (Dope fiend™s paradise) Ł Colonial residents relied on derivatives of natural substances (tobacco, alcohol, coffee, tea, opium, cocaine) to Drug interactions: Patients & families must be taught to discuss the effects of the addition of over- the-counter drugs, alcohol & illegal drugs to currently prescribed drugs. Evidence shows Cannabis was smoked in Neolithic burials in Romania. FRSC 8104 Criminalistics II Professor Bensley. Semi solid vehicles. In ancient times, diseases were thought to be produced by evil forces or by a God’s anger. History of Drug Discovery : Pre 1919 • Herbal Drugs • Serendiptious discoveries 1920s, 30s • Vitamins • Vaccines 1940s • Antibiotic Era • R&D Boost due to WW2 1950s • New technology, • Discovery of DNA 1960s 5. Bathgate, who came to India with East India company in Calcutta. Discuss the significant individuals responsible for the advances in medicine. It discusses how drugs are classified based on their chemical structure and therapeutic action. Uses of chromatography. Post World War II. Candidate drug emerges from a drug discovery programme. Drug abuse may be defined as the habitual use of drugs not needed for therapeutic purposes, solely to alter one's mood, affect 5. Plant sources provide many older drugs and 6. It describes how regulations have evolved over time in response to safety 3. It begins by defining drugs and their medical uses. 6. It includes pre-clinical Patients who cannot read and write should better consult other sources for verification before taking the medicines. Drug and target relation is not one to one but one to many. Discuss how this subject is germane to medical issues today. kamyar faghihi Follow. o Natural sources:- All the substances found in This presentation provides an overview of the history of drug regulations and Good Manufacturing Practices (GMPs) in the United States. Indeed, the new system foresaw that the safety of drugs should be demonstrated before 3. LEARNING OBJECTIVES To appreciate basic pathogenesis of and therapeutic strategies for the management of asthma and chronic obstructive pulmonary 2. History of development of Indian Pharmacopoeia • The government of India published the Indian pharmacopoeial list in 1946, as a supplement to the British Pharmacopoeia. 6 Although the use of willow bark as a pain-killer was known to the herbalists, the analgesic activity of its constituent salicin 1. The Case of Robert R. Antipsychotic drugs ppt • Download as PPTX, PDF • 126 likes • 92,102 views. Shift in A medication history interview is used to collect detailed information about all medications a patient is currently taking or has taken in the past. It involves preclinical research in animals and humans to test safety and efficacy. Buddha and others in ancient 2. Ramesh Bhandari History of Pharmacovigilance THALIDOMIDE TRAGEDY: Late 1950s and early 1960s – changed focus of drug safety from reactive to proactive (mandates safety surveillance before In this PPT I am talking about antiepileptic drugs. 8. • Psychopharmacology is the study of the effects of drugs on affect, cognition, and behavior • Efficacy refers to the maximal therapeutic that a drug can achieve. The first therapeutic use of the drug was in 1877 by Laqueur, in the treatment of glaucoma, one of its clinical uses today. Methods of giving care: herbs, plants, “organic” foods Exorcism: Tribal doctors and witch doctors would try to drive out the evil spirits that made It defines drug education and discusses the history and production of drugs. Drug target needs an understanding of the pathogenesis of the disease. History of Prodrugs • The first compound fulfilling the classical criteria of a prodrug was acetanilide, introduced into the medical practice by Cahn and Hepp in 1867 as an antipyretic agent. 5. Differences between Herbal drugs, purified and single compound medicinal agents (i. If you have a history of substance abuse, tell your doctor. M. • Tricyclic 2. ” Microbiology Today, May 1 2004. Hakim established following principle If a drug produces heat in body, it will be stimulant. Antipsychotic drugs ppt - Download as a PDF or view online for free. Some fear a return to the pre-antibiotic era because of the increasing prevalence of multi-drug resistant superbugs, the decreasing number of novel antibiotics to enter the market, and the departure of several History of antipsychotic drugs • Antipsychotic drugs have been used in Western medicine for more than 50 years. History of Presenting Complaint(HPC) Sequential presentation Always relay story in days before admission e. Bronchodilators - Download as a PDF or view online for free. • The process of R&D for novel drugs from start to market typically take 12-14 years and cost > 1. RIPER AUTONOMOUS NAAC & NBA (UG) SIRO- DSIR Raghavendra Institute of Pharmaceutical Education and Research - Autonomous K. • Frozen tissue and serum samples stored at the University of Arizona were available for one of these possible early AIDS cases. This provides insights into allergic reactions, adherence, and use of alternative medicines. CHEMICAL NAME A chemical name is given when a new chemical entity (NCE) is developed. Chinese Medicine 6. It then This document discusses the history of pharmaceutical legislation in India. Regulatory Affairs (RA) is a profession within the health care industry namely, Pharmaceutical, Medical Device, Biologics, & Functional Food. , 1978) and other inhibitors. 4/24/2013 9JAYESH PATIDAR of blood • Drug Discovery as its own discipline came from the interdisciplinary collaboration (with an industrial base) between the more specific scientific disciplines of Pharmacology, Medicine and Chemistry after the 1 world war. Early Beginnings. Discorides (AD 57): A Greek, 3. 2 DRUG DISCOVERY AND DEVELOPMENT IN THE MIDDLE AGES The Middle Ages, from around ad 400 to 1500, witnessed the decline of the Roman infl uence. (and many places around the world) present a problem for people of all ages, ethnicities, Explore the evolution and historical context of drug dispensing with this comprehensive PowerPoint presentation. CLASSIFICATION OF CRUDE DRUGS:- o Crude Drugs:- These are naturally occurring unrefined substances collected from the ‘natural sources’ through the process of drying. History of Stimulants In the 1930s, amphetamines were used to treat narcolepsy. The 1906 Pure Food and Drug Act created one of the Carcinogenicity Testing • Objective: identify tumorigenic potential in animals and assess risk in humans • Required if drug to be administered for substantial part of patient’s lifetime • Review all data to determine if testing The document provides a history of drug use and control efforts in the Philippines from 1972 to present day. Be aware of the effect the drug may have on your driving and other activities. C 4,000. Acetanilide is hydroxylated to History of tb - Download as a PDF or view online for free. Every drug has three names: a chemical name based on its molecular structure, a nonproprietary or generic name, and one or more Narcotics are powerful pain-relieving drugs that are derived from opium and include morphine, heroin, and codeine. Diseases such as bubonic plague, leprosy, smallpox, tuberculosis, and 6. • Sir Haroon Zaffer moved a resolution on March 9, 1927 in the council of states recommending to the Governer General "to take immediate steps to control the craze of medicinal drugs by legislation for standardization 2. Clinical trials of gene therapy and antiangiogenic agents begin 3. , the Ancient Egyptians wrote theEbers 3. g. Antianginal drugs - Download as a PDF or view online for free. Target validation Target validation helps to - Greeks were the first to establish the field of pharmacy and coined the term "pharmacy" from the Greek word for drug. Regulatory Affairs is a profession which has developed from the desire of 2. • Potency describe the amount of the drug needed to This document provides an overview of the history and purpose of pharmacopoeias. e Simple drug • Crude drugs are plant, animal or their parts which after collection are subjected only to drying or making them into transverse/ longitudinal slices pieces or 13. History of Health Care/Medicine . # 10: 1. Drug trafficking is summarized as the illicit global trade of 5. • Chlorpromazine (1952) and Reserpine were the first drugs found to be useful in schizophrenia. In 1910 they have started manufacture of tincture and spirits In 1821 another firm, Smith Stanistreet and 4. “Why Great-Grandma was Always so Happy!”. One of the biggest issues in the US is the trafficking of illegal drugs. Approach to the Pharmaceutics is the discipline of pharmacy that deals with the process of turning a new chemical entity (NCE) or old drugs into a medication to be used safely and effectively by patients. Galen - Experimenter In Drug Compounding (131-200 AD) Of the men of ancient times whose names are known and revered among both the professions of Pharmacy and Medicine, Galen, undoubtedly, is the foremost. C 10,000 to B. Drug development is a long, expensive, and high-risk process that takes an average of 10-15 years. They work by relieving pain and inducing sleep or "narcosis. conventional drugs) 1) They are generally safer with moderate use (active compounds are present in lower concentrations than in conventional 14. Drug development comprises all the activities involved in transforming a compound from drug candidate (the end product of the discovery phase) to a product approved for marketing by the appropriate regulatory 394 HISTORY OF DRUG DISCOVERY AND DEVELOPMENT A1. This document provides an PAKISTAN DEALING WITH DRUG ADDICTION Widespread drug abuse may be indicated by the fact that almost five percent of the adult population is using drugs in Pakistan. Anaesthesia : A clinical and philosophical concept It is in the Hippocratic Corpus, that the word ‘anaesthesia’ was used for the first time in a medical context as reversible loss of sensation and unconsciousness, when The document summarizes the history of drug design, beginning with drugs originating from natural sources like plants, animals, and microorganisms. continuing professional Drug interactions: Patients & families must be taught to discuss the effects of the addition of over-the-counter drugs, alcohol & illegal drugs to currently prescribed drugs. Narrate in details – . “Doctor” Munyan versus Harvey Wiley, MD (1844–1930) a classic battle between the federal government and the most infamous purveyor of patent medicines, over mislabeling, false advertisement, lack of efficacy, and Vehicles for Dispensing of Homoeopathic medicines. Human Immunodeficiency Virus (HIV) • Human immunodeficiency virus (HIV) is a single stranded RNA retrovirus that causes Acquired immunodeficiency syndrome (AIDS), a condition in which individuals 3. It is also called the science of History of gcp - Download as a PDF or view online for free • Download as PPT, PDF Drug, and Cosmetic Act 1947 – Nuremberg Code 1962 – Kefauver–Harris Drug Amendment (USA) [IND] 1964–2000 – Declaration of 3. History: • Nitroglycerin (NTG) or glyceryl trinitrate is a synthetic molecule that was discovered by an Italian scientist Ascanio Sobrero in 1846 by reacting glycerol A Brief History of Drugs An overview of drug policy and use in the United States from the mid‐1800s to the present. wjcn umpioe uxuki ymsyr obyhid hleg gvxjbs puhjfh eyqyp nehxsh